Find recruiting clinical trials for heart failure in the UK — from guideline-directed medical therapy to device-based interventions. See where trials fit into your treatment pathway.
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See where clinical trials fit into your care journey
Guideline-Directed Medical Therapy — the four pillars
Standard: ACEi/ARB/ARNI + Beta-blocker + MRA + SGLT2 inhibitor (dapagliflozin or empagliflozin)
When standard GDMT isn't enough
Standard: Hydralazine+nitrate (Black patients), ivabradine, digoxin, or diuretic optimisation
For patients meeting device criteria
Standard: ICD (implantable cardioverter-defibrillator), CRT (cardiac resynchronisation therapy)
When conventional therapies no longer control symptoms
Standard: LVAD (left ventricular assist device), heart transplant evaluation, or palliative care
Heart failure means the heart can't pump blood effectively. Affects over 900,000 people in the UK. Symptoms include breathlessness, ankle swelling, and fatigue. Can be caused by heart attacks, high blood pressure, or valve disease.
Treatments have improved dramatically (SGLT2 inhibitors, ARNI), but many patients still deteriorate. Trials are testing gene therapies, novel molecules, and device innovations that could further improve survival and quality of life.
Heart failure with preserved ejection fraction (HFpEF) affects about half of all HF patients but has fewer treatment options. Many new trials specifically target HFpEF — a major unmet need in cardiology.
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